Self-interest to some extent is normal and healthy. Of course you're going to look after yourself to make sure you stay financially stable and ensure that you aren't being taken advantage of. Normal and mature self-interest dictates that you take care of yourself, so that you can take care of others.
However, the self-interest of Ayn Rand goes beyond self-preservation and headlong into the pit of narcissism and greed. It doesn't say "I'll help you so one day maybe you can help me". Instead it says "Fuck you, I got mine." It doesn't say "Do unto others as you would have them do unto you" as Jesus said in the Bible. Instead it says "Do unto others before they do unto you." It is an unhealthy atheistic nihilism which dictates that the ends justify the means and that he who dies with the most toys wins. It teaches that there is no moral code which binds us as species to look out for the less fortunate and that crawling to the top on the backs of others is ok.
I suppose if you are a complete nihilist which believes in no higher power, authority or any responsibility to those you use on your way through this life, maybe "Atlas Shrugged" is your thing. Yet, you cannot call yourself a Christian, a Jew, a Muslim or a member of any other religion without acknowledging that you are ignoring the teachings of that religion by being an ego-centric prick. Man is not an island. We weren't predestined to start making "good choices" and working hard at the age of 3, we had help along the way. Nobody got to where they are today without a little help from the right people at the right time. There's many people who worked hard for decades, only to see their jobs shipped overseas or people like myself who worked hard and did the right thing, only to have it come back to bite them in the ass.
Remember how I said in a previous article that the "Anti-Christ was already here"? Well, that entity is here but it isn't a person, it is an idea. It is the perception of the vast majority of the public that they are number one, that they are the most important entity in the universe. It is the belief that the individual is responsible to no one and fucking over other people is OK if that is what it takes to survive.
Personally, I would prefer to shuffle off this mortal coil with a clear conscience and poor, surrounded by people who love me than to die rich and alone. I hope I am not the only one.